Billie Jean King The 10-time Grand Slam winner spoke to actor Julia Louis-Dreyfus on the podcast Wiser Than Me about her decision to try a GLP-1. “I’m a binge eater, ” said the now 82-year-old King. “Every morning, I wake up, I tell myself I have an eating disorder. … It’s interesting with the new injections, you know, with the Ozempics of the world. It’s very interesting because my doctor wants me to try it.” She later revealed that she had already started the medication and hoped that it would help quiet the food noise in her mind.e60dc2a1-f33c-4a05-9b50-8e3e8e597629c1903c23-9b54-4c29-997e-2db9df0a5d3a
Kathy Bates The Oscar winner has lost 100 lb over the past seven years — 80 through lifestyle changes and the final 20 with Ozempic. The journey began after a type 2 diabetes diagnosis that inspired her to “get serious about her health,” she said in a 2024 interview.e60dc2a1-f33c-4a05-9b50-8e3e8e597629ebe01c5d-6980-4a06-b411-f91fe45dc91b “It was hard work … especially during the pandemic,” said Bates. The actor also shared her plans to work out more, with activities like walking and Pilates, in order to maintain her weight loss.
The Takeaway Celebrities, including Serena Williams and Charles Barkley, have spoken openly about taking GLP-1 medications, helping reduce stigma. These stars describe both the benefits and challenges of Ozempic, Wegovy, Zepbound, and Mounjaro. Their stories show how GLP-1s can be transformative for some people but are not a permanent solution for others.
Charles Barkley The former professional basketball star said he lost around 60 lb by taking Mounjaro, in addition to exercising and maintaining a healthy diet. “It’s been great. I’m starting to feel like a human being,” Barkley revealed on The Pat McAfee Show , according to a post on X . Describing his experience, he said, “It’s been amazing,” and added that his ultimate goal is to live longer. “I started at 352, and I’m down to 290,” with an ultimate goal of 270, he said.e60dc2a1-f33c-4a05-9b50-8e3e8e59762923145969-36ed-4ba4-9fff-91b195ce2812
Amy Schumer Schumer’s first go-round with a GLP-1 didn’t go well. On a 2023 episode of the talk show Watch What Happens Live With Andy Cohen , the comedian and actor said she was “one of those people that felt so sick” taking Ozempic, which led her to discontinue it.e60dc2a1-f33c-4a05-9b50-8e3e8e5976298b03560f-8d45-44b3-9030-207755027961 Three years later, in 2025, the actor reported that she was having “a really good experience” taking a different weight loss drug, Mounjaro, along with hormone replacement therapy for perimenopause symptoms.e60dc2a1-f33c-4a05-9b50-8e3e8e597629958cb861-46f7-4910-a98e-6f920cc3614d
Oprah Winfrey In March 2024, Winfrey hosted a prime-time show on ABC titled An Oprah Special: Shame, Blame, and the Weight Loss Revolution , in which she talked about all things GLP-1, including her personal success on these drugs.e60dc2a1-f33c-4a05-9b50-8e3e8e597629133f846c-7d5b-4432-94f4-d58023658ad0 “In my entire life, I never dreamed that we would be talking about medicines that are providing hope for people like me who have struggled for years with being overweight or with obesity,” she told People magazine.e60dc2a1-f33c-4a05-9b50-8e3e8e5976299ad8ffe6-e058-4c42-be8b-f36634188fcc But she didn’t reveal one setback she’d had on her health journey. In a later interview with People , published in December 2025, Winfrey revealed that just six months after starting GLP-1s, she’d decided to see if she could “beat the medication” by stopping taking them. Her goal was to prove she could maintain the weight loss on her own. Over the next 12 months, however, she regained about 20 pounds (lb) and had valuable new insight into GLP-1 use. “It’s going to be a lifetime thing,” Winfrey said. “I’m on high blood pressure medication, and if I go off the high blood pressure medication, my blood pressure is going to go up. The same is true, I now realize, with these medications. I’ve proven to myself I need it.”e60dc2a1-f33c-4a05-9b50-8e3e8e5976297a40baa9-255d-46e9-83c8-ad7660528163
What Celebrities Have Said About Taking GLP-1s GLP-1 medications are no longer Hollywood’s “worst kept secret.” From award-winning actors to sports icons, more and more celebrities are sharing how GLP-1 drugs like Ozempic, Wegovy, Zepbound, and Mounjaro have shaped their weight loss experiences. Their honesty is helping to shift the conversation away from shame and toward real talk about managing weight and the impact it can have on all aspects of life, including physical and mental health. Here are 15 well-known figures who’ve shared their GLP‑1 journeys — what worked, what didn’t, and how it’s changed them. These celebrities are reducing the stigma around GLP-1s. default Oprah Winfrey, Anthony Anderson, and Elon Musk have all reportedly taken a GLP-1 drug.
Elon Musk When one fan asked the billionaire owner of X in 2022, “What’s your secret? You look awesome, fit, ripped, and healthy. Lifting weights? Eating healthy?” Musk credited fasting and Wegovy for his transformation.e60dc2a1-f33c-4a05-9b50-8e3e8e597629ce83332b-373b-4d7d-b504-7a8dcdf0912e The Tesla and SpaceX chief has said he wants to make the drug more accessible to all Americans, posting on X in 2024 that “nothing would do more to improve the health, lifespan, and quality of life for Americans” than making GLP-1s “super low cost to the public.”
Rebel Wilson The star of Pitch Perfect and The Hustle shared that she used Ozempic for a period of time to maintain the weight loss she experienced when she made 2020 her “year of health” and lost 77 lb.e60dc2a1-f33c-4a05-9b50-8e3e8e5976298962a22a-308e-49b8-96af-47ed1e5530b3 “Someone like me could have a bottomless appetite for sweets, so I think those drugs can be good,” she later said in a 2024 interview. Wilson added that she was no longer using GLP-1s and was happy with her current “still curvy and solid” weight.e60dc2a1-f33c-4a05-9b50-8e3e8e597629afef3a50-e3b8-4c66-b9bd-21a5a8b1d9b8 “I feel strongly that young women shouldn’t try to obsess over looking like Victoria’s Secret models — they should just look like themselves. … I know that my relationship with food is complicated,” she also said.e60dc2a1-f33c-4a05-9b50-8e3e8e59762938e4fde4-0bab-4f25-b0f8-965d414aa886
Rosie O’Donnell The actor and comedian first revealed on TikTok that she had shed 10 lb on Mounjaro, and then followed it up with another post about how she lost 15 lb on the lowest dose.e60dc2a1-f33c-4a05-9b50-8e3e8e5976290d360477-6ee2-44ad-a118-ddc17f0d2015 Two years later, O’Donnell is still “shocked” by the transformation of her body. In addition to staying on the weight loss drugs, the actor eats less sugar, drinks water, and tries to move more.e60dc2a1-f33c-4a05-9b50-8e3e8e597629096e940b-5919-4bed-90dc-acaf235ee1c5
Serena Williams The tennis legend revealed in summer 2025 that after having her second child she lost 31 lb by using the GLP‑1 drug Zepbound (tirzepatide) . In an interview with People , she emphasized that even after extensive sports training and healthy eating, she felt stuck.e60dc2a1-f33c-4a05-9b50-8e3e8e597629c0d96df3-da28-4bf5-a760-707ae59bd4cd “I knew my body was missing something it needed. For me, the answer was GLP-1s,” Williams said. As a paid ambassador for Ro, a telehealth GLP-1 provider, she’s using her platform to emphasize that using a weight loss drug “isn’t a shortcut, it’s healthcare.” And that the drug is part of an overall plan that also includes a healthy diet and exercise.e60dc2a1-f33c-4a05-9b50-8e3e8e5976295117d259-e457-435e-9fa8-6d2482057a62 “I feel like I have a lot of energy and it’s great. I just feel pretty good about it,” said Williams.
GLP-1s aren’t just for the stars. Explore our recommendations for the best ways to buy weight loss medications online.
Tracy Morgan The comedian and former star of The Last O.G. made headlines when he shared on Today in 2023 that he was taking Ozempic. “That’s how this weight got lost. … I went and got a prescription and I got Ozempic. I’m not letting it go,” he said.e60dc2a1-f33c-4a05-9b50-8e3e8e597629295c506f-7f57-4d50-8139-108897f69926 Morgan has continued to praise the drug, saying, “Ozempic did great by me, and I was glad to use it. I take Ozempic every Thursday,” as E! News reported. “It cuts my appetite in half.”e60dc2a1-f33c-4a05-9b50-8e3e8e597629df4165b4-1eec-4c1f-846c-cf3f7ce51f83
Whoopi Goldberg In 2024, the actor and talk show personality revealed to her cohosts on The View that she took Mounjaro (tirzepatide) to lose a significant amount of weight. “I will tell you, I weighed almost 300 lb when I made [the 2022 film] Till . I had taken all those steroids, I was on all this stuff, and one of the things that helped me drop the weight was the Mounjaro. That’s what I used.”e60dc2a1-f33c-4a05-9b50-8e3e8e597629db765d1a-96ec-4f57-bd3e-1e39cd172a39 Goldberg also discussed how all the constant chatter around people’s appearance can be harmful — and how everyone should be nicer to themselves and others. “Maybe the key is to stop judging everybody. Maybe that’s the key,” she said.
Jim Gaffigan The comedian and author of the bestselling book Dad Is Fat , shared in an interview with People that after his weight reached 270 lb, he tried Mounjaro and lost 50 lb, crediting the drug with helping him feel better, lighter, and more alive. “I’m just grateful because it’s such a better life,” he said.e60dc2a1-f33c-4a05-9b50-8e3e8e597629eb8ab80d-3f62-499f-84df-be0853dca202 Gaffigan is puzzled by the stigma around the medication, which is part of the reason he wanted to talk about it. “I don’t think there’s anything wrong with it. … It’s just whatever gets you through,” he said.
Claudia Oshry For Oshry, a comedian, cohost of the podcast The Toast , and creator of the popular Instagram account @girlwithnojob, taking a GLP-1 was a no-brainer. She told listeners on her podcast, “You thought they were going to make a weight loss drug and I wasn’t going to take it?”e60dc2a1-f33c-4a05-9b50-8e3e8e597629704e6254-3590-4e6a-8d33-a8592c8bc892 She joked at the time that she would regain the weight because her Ozempic use wasn’t permanent. In a 2024 interview, she revealed that she’d stopped taking the medication when she and her husband, Ben Soffer, decided to have kids.e60dc2a1-f33c-4a05-9b50-8e3e8e597629f3c51519-9876-4cb7-92c6-e31170c9bfc9
Meghan Trainor The “All About That Bass” singer and her husband, actor Daryl Sabara, took the lowest drug dose and combined the medication with exercise and balanced meals in a weight loss journey made for two. The Grammy winner took to social media to respond to people who kept commenting on her transformation after her appearance at Billboard’s 2025 Women in Music Awards. “No, I don’t look like I did 10 years ago. I’ve been on a journey to be the healthiest, strongest version of myself for my kids and for me. I’ve worked with a dietitian, made huge lifestyle changes, started exercising with a trainer, and yes, I used science and support (shoutout to Mounjaro!) to help me after my 2nd pregnancy. And I’m so glad I did because I feel great,” Trainor wrote on Instagram .
Chelsea Handler Surprisingly, the comedian didn’t know she was taking Ozempic when she first received a prescription, she said in an interview on the Call Her Daddy podcast. “My anti-aging doctor just hands it out to anybody,” Handler said. “I didn’t even know I was on it.” Apparently, that doctor suggested she take it “if you ever want to drop five pounds.” Handler later realized she was on the medication when she told a friend she was taking semaglutide, and her friend said it was Ozempic. Since then, Handler has stopped taking the medication.e60dc2a1-f33c-4a05-9b50-8e3e8e597629ff5b84a1-af29-41c5-84b3-42cebbf7f2d4